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Academic Journal

Canonical non-homologous end-joining promotes genome mutagenesis and translocations induced by transcription-associated DNA topoisomerase 2 activity.

  • Authors : Olmedo-Pelayo J; Instituto de Biomedicina de Sevilla (IBiS), Hospital Virgen del Rocío-CSIC-Universidad de Sevilla, 41013 Seville, Spain.; Departamento de Genética, Universidad de Sevilla, 41080 Seville, Spain.

Subjects: Translocation, Genetic*; DNA End-Joining Repair/DNA End-Joining Repair/DNA End-Joining Repair/*genetics ; DNA Topoisomerases, Type II/DNA Topoisomerases, Type II/DNA Topoisomerases, Type II/*genetics

  • Source: Nucleic acids research [Nucleic Acids Res] 2020 Sep 18; Vol. 48 (16), pp. 9147-9160.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print Cited Medium: Internet ISSN:

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Academic Journal

DSB structure impacts DNA recombination leading to class switching and chromosomal translocations in human B cells.

  • Authors : So CC; Department of Immunology, University of Toronto, Toronto, Ontario, Canada.; Martin A

Subjects: DNA Breaks, Double-Stranded* ; Immunoglobulin Class Switching* ; Translocation, Genetic*

  • Source: PLoS genetics [PLoS Genet] 2019 Apr 04; Vol. 15 (4), pp. e1008101. Date of Electronic Publication: 2019 Apr 04 (Print Publication: 2019).Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: eCollection Cited Medium: Internet

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Academic Journal

Requirement for Parp-1 and DNA ligases 1 or 3 but not of Xrcc1 in chromosomal translocation formation by backup end joining.

  • Authors : Soni A; Institute of Medical Radiation Biology, University of Duisburg-Essen Medical School, 45122 Essen, Germany.; Siemann M

Subjects: DNA End-Joining Repair* ; Translocation, Genetic*; DNA Ligases/DNA Ligases/DNA Ligases/*physiology

  • Source: Nucleic acids research [Nucleic Acids Res] 2014 Jun; Vol. 42 (10), pp. 6380-92. Date of Electronic Publication: 2014 Apr 19.Publisher: Oxford University Press Country of Publication: England NLM ID: 0411011 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Microhomology directs diverse DNA break repair pathways and chromosomal translocations.

  • Authors : Villarreal DD; Department of Cellular and Structural Biology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, United States of America.; Lee K

Subjects: DNA Breaks, Double-Stranded* ; DNA End-Joining Repair*; DNA Replication/DNA Replication/DNA Replication/*genetics

  • Source: PLoS genetics [PLoS Genet] 2012; Vol. 8 (11), pp. e1003026. Date of Electronic Publication: 2012 Nov 08.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Clinical and molecular studies in four patients with SRY-positive 46,XX testicular disorders of sex development: implications for variable sex development and genomic rearrangements.

  • Authors : Nakashima S; Department of Pediatrics, Hamamatsu University School of Medicine, Hamamatsu, Japan.; Ohishi A

Subjects: Chromosomes, Human, X* ; Chromosomes, Human, Y* ; Genes, sry*

  • Source: Journal of human genetics [J Hum Genet] 2014 Oct; Vol. 59 (10), pp. 549-53. Date of Electronic Publication: 2014 Aug 07.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 9808008 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Mechanisms of oncogenic chromosomal translocations.

  • Authors : Byrne M; Department of Medicine, University of Florida College of Medicine, Gainesville, Florida.; Wray J

Subjects: Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/Cell Transformation, Neoplastic/*genetics ; Poly(ADP-ribose) Polymerases/Poly(ADP-ribose) Polymerases/Poly(ADP-ribose) Polymerases/*physiology ; Translocation, Genetic/Translocation, Genetic/Translocation, Genetic/*genetics

  • Source: Annals of the New York Academy of Sciences [Ann N Y Acad Sci] 2014 Mar; Vol. 1310, pp. 89-97. Date of Electronic Publication: 2014 Feb 16.Publisher: New York Academy of Sciences Country of Publication: United States NLM ID: 7506858 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Methylation of the nonhomologous end joining repair pathway genes does not explain the increase of translocations with aging.

  • Authors : Martín-Guerrero I; Department of Genetics, Physical Anthropology and Animal Physiology, Faculty of Medicine and Odontology, University of the Basque Country UPV/EHU, Barrio Sarriena sn, 48940, Leioa, Bizkaia, Spain.; de Prado E

Subjects: Aging/Aging/Aging/*genetics ; DNA End-Joining Repair/DNA End-Joining Repair/DNA End-Joining Repair/*genetics ; DNA Methylation/DNA Methylation/DNA Methylation/*genetics

  • Source: Age (Dordrecht, Netherlands) [Age (Dordr)] 2014; Vol. 36 (6), pp. 9730. Date of Electronic Publication: 2014 Nov 16.Publisher: Springer Country of Publication: Netherlands NLM ID: 101250497 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

End-joining, translocations and cancer.

  • Authors : Bunting SF; Rutgers University, Center for Advanced Biotechnology and Medicine, Piscataway, New Jersey 08854, USA. ; Nussenzweig A

Subjects: DNA End-Joining Repair/DNA End-Joining Repair/DNA End-Joining Repair/*physiology ; Genomic Instability/Genomic Instability/Genomic Instability/*genetics ; Neoplasms/Neoplasms/Neoplasms/*genetics

  • Source: Nature reviews. Cancer [Nat Rev Cancer] 2013 Jul; Vol. 13 (7), pp. 443-54. Date of Electronic Publication: 2013 Jun 13.Publisher: Nature Pub. Group Country of Publication: England NLM ID: 101124168 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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Academic Journal

Yeast pol4 promotes tel1-regulated chromosomal translocations.

  • Authors : Ruiz JF; Centro de Biología Molecular 'Severo Ochoa', Universidad Autónoma de Madrid/CSIC, Madrid, Spain. ; Pardo B

Subjects: DNA Breaks, Double-Stranded*; DNA Polymerase beta/DNA Polymerase beta/DNA Polymerase beta/*genetics ; Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/Intracellular Signaling Peptides and Proteins/*genetics

  • Source: PLoS genetics [PLoS Genet] 2013; Vol. 9 (7), pp. e1003656. Date of Electronic Publication: 2013 Jul 18.Publisher: Public Library of Science Country of Publication: United States NLM ID: 101239074 Publication Model: Print-Electronic Cited Medium: Internet

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Academic Journal

Tp53 deletion in B lineage cells predisposes mice to lymphomas with oncogenic translocations.

  • Authors : Rowh MA; Immunology Graduate Group, University of Pennsylvania School of Medicine, Philadelphia, PA, USA.; DeMicco A

Subjects: Cell Lineage* ; Translocation, Genetic*; B-Lymphocytes/B-Lymphocytes/B-Lymphocytes/*immunology

  • Source: Oncogene [Oncogene] 2011 Nov 24; Vol. 30 (47), pp. 4757-64. Date of Electronic Publication: 2011 May 30.Publisher: Nature Publishing Group Country of Publication: England NLM ID: 8711562 Publication Model: Print-Electronic Cited Medium: Internet ISSN:

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